metaPreg - Antimycotic Azoles (all routes except local only) during pregnancy

Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.03 [0.99, 1.08]	0%	11 studies	179,419	49,549	low	ROB	-
Major congenital malformations	1.11 [0.99, 1.24]	0%	8 studies	99,423	9,544	not evaluable	ROB	-
Congenital heart defects	1.04 [0.81, 1.34]	53%	5 studies	35,016	45,382	not evaluable	ROB	-
Cleft lip with or without cleft palate	1.27 [0.80, 2.00]	41%	4 studies	6,111	45,061	not evaluable	ROB	-
Limb defects	0.99 [0.87, 1.12]	0%	4 studies	22,513	46,635	not evaluable	ROB	-
Cleft palate	0.86 [0.57, 1.29]	0%	3 studies	3,309	45,007	not evaluable	ROB	-
Craniosynostosis	0.94 [0.48, 1.82]	0%	3 studies	2,767	7,400	not evaluable	ROB	-
Diaphragmatic hernia	1.64 [0.67, 4.04]	11%	3 studies	1,353	7,401	not evaluable	ROB	-
Tetralogy of Fallot	2.18 [0.93, 5.13]	68%	3 studies	2,273	45,009	not evaluable	ROB	-
Ventricular septal defect	1.08 [0.90, 1.29]	13%	3 studies	13,348	45,008	not evaluable	ROB	-
Ano-rectal atresia and stenosis	2.27 [0.88, 5.88]	0%	2 studies	1,286	50	not evaluable	ROB	-
Atrial septal defect	1.12 [0.43, 2.87]	50%	2 studies	7,665	37,658	not evaluable	ROB	-
Atrioventricular septal defect	1.57 [0.28, 8.69]	62%	2 studies	372	37,655	not evaluable	ROB	-
Ear malformations	1.08 [0.24, 4.90]	35%	2 studies	14	45,000	not evaluable	ROB	-
Eye defects	1.01 [0.64, 1.59]	0%	2 studies	1,562	38,961	not evaluable	ROB	-
Gastroschisis	0.35 [0.07, 1.81]	0%	2 studies	1,867	46	not evaluable	ROB	-
Genital anomalies	1.31 [0.71, 2.39]	68%	2 studies	10,049	38,961	not evaluable	ROB	-
Hypoplastic left heart (HLH/HLHS)	2.21 [0.81, 6.02]	0%	2 studies	847	7,359	not evaluable	ROB	-
Hypospadias	0.66 [0.25, 1.78]	2%	2 studies	3,335	50	not evaluable	ROB	-
Nervous system anomalies	1.14 [0.93, 1.39]	0%	2 studies	5,183	38,961	not evaluable	ROB	-
Oro-facial clefts	0.84 [0.60, 1.16]	0%	2 studies	2,128	37,970	not evaluable	ROB	-
Polydactyly	1.05 [0.47, 2.38]	0%	2 studies	603	7,674	not evaluable	ROB	-
Single ventricle	1.28 [0.59, 2.80]	0%	2 studies	174	37,654	not evaluable	ROB	-
Spina bifida	2.87 [0.76, 10.88]	0%	2 studies	1,280	330	not evaluable	ROB	-
Total anomalous pulm venous return	0.75 [0.34, 1.63]	0%	2 studies	303	37,654	not evaluable	ROB	-
Transposition of the great vessels	2.56 [0.46, 14.10]	75%	2 studies	1,532	37,657	not evaluable	ROB	-
Urinary malformations	0.99 [0.68, 1.45]	44%	2 studies	8,392	38,961	not evaluable	ROB	-
Common arterial truncus	28.45 [5.69, 142.20]	-	1 study	138	8	not evaluable	ROB	56.39 [10.86; .]
Double outlet right ventricle	10.13 [1.21, 84.53]	-	1 study	192	7	not evaluable	ROB	19.74 [1.72; .]
Oesophageal atresia with or without tracheo-oesophageal fistula	5.13 [1.03, 25.46]	-	1 study	756	8	not evaluable	ROB	9.73 [1.22; .]
Pulmonary artery stenosis	26.34 [1.26, 548.75]	-	1 study	2	7,352	not evaluable	ROB	52.18 [1.84; .]
Tricuspid atresia and stenosis	10.87 [1.30, 90.74]	-	1 study	179	7	not evaluable	ROB	21.22 [1.93; .]
28 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.19 [0.78, 1.80]	35%	4 studies	42	1,529	not evaluable	ROB	-
Low birth weight (< 2500g)	1.03 [0.71, 1.48]	0%	3 studies	5	1,400	not evaluable	ROB	-
2 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	-	-	0 study					-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal disorders (as a whole)	0.80 [0.57, 1.11]	0%	2 studies	66	319	not evaluable	ROB	-
Low Apgar score (< 7) (at 1 min)	-	-	0 study					-
Low Apgar score (< 7) (at 5 min)	-	-	0 study					-
Persistent pulmonary hypertension	-	-	0 study					-
Very low Apgar score (< 5) (at 1 min)	-	-	0 study					-
Very low Apgar score (< 5) (at 5 min)	-	-	0 study					-
1 non statistically significant endpoints reported in only one study
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks)	0.93 [0.70, 1.23]	0%	6 studies	1,236	16,677	not evaluable	ROB	-
Early intrauterine death (< 22 weeks)	2.01 [1.34, 3.00]	88%	5 studies	30,290	6,538	not evaluable	ROB	3.43 [2.02; .]
Elective/induced termination of pregnancy	4.52 [2.31, 8.84]	20%	3 studies	80	631	not evaluable	ROB	8.51 [4.05; .]
Intrauterine deaths (as a whole or unspecified)	1.75 [1.47, 2.09]	-	1 study	54	199	not evaluable	ROB	2.90 [2.30; .]
1 non statistically significant endpoints reported in only one study