Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17748
R75069		 De Santis - Itraconazole, 2009 Low birth weight (<2500 g) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.28 [0.03;2.56] C 1/152   4/175 5 152
ref
S17736
R74933		 Norgaard - Fluconazole, 2008 Low birth weight 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.10 [0.70;1.60] -/1,079   -/170,453 - 1,079
ref
S17733
R74845		 Mastroiacovo - Fluconazole, 1996 Low birth weight (LBW) (defined as <2500 gm) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose Matched 0.92 [0.38;2.19] -/169   -/389 - 169
ref
Total 3 studies 1.03 [0.71;1.48] 5 1,400
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Santis - Itraconazole, 2009De Santis - Itraconazole, 2009 0.28[0.03; 2.56]51523%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Norgaard - Fluconazole, 2008Norgaard - Fluconazole, 2008 1.10[0.70; 1.60]-1,07979%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Mastroiacovo - Fluconazole, 1996Mastroiacovo - Fluconazole, 1996 0.92[0.38; 2.19]-16918%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.03[0.71; 1.48]51,4000.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.71; 1.48]51,4000%NADe Santis - Itraconazole, 2009 Norgaard - Fluconazole, 2008 Mastroiacovo - Fluconazole, 1996 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.71; 1.48]51,4000%NADe Santis - Itraconazole, 2009 Norgaard - Fluconazole, 2008 Mastroiacovo - Fluconazole, 1996 3 Tags Adjustment   - No  - No 0.28[0.03; 2.56]5152 -NADe Santis - Itraconazole, 2009 1   - Yes  - Yes 1.06[0.73; 1.55]-1,2480%NANorgaard - Fluconazole, 2008 Mastroiacovo - Fluconazole, 1996 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.06[0.73; 1.55]-1,2480%NANorgaard - Fluconazole, 2008 Mastroiacovo - Fluconazole, 1996 2 MatchedMatched 0.78[0.35; 1.77]53210%NADe Santis - Itraconazole, 2009 Mastroiacovo - Fluconazole, 1996 2 All studiesAll studies 1.03[0.71; 1.48]51,4000%NADe Santis - Itraconazole, 2009 Norgaard - Fluconazole, 2008 Mastroiacovo - Fluconazole, 1996 30.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.71; 1.48]51,4000%NADe Santis - Itraconazole, 2009 Norgaard - Fluconazole, 2008 Mastroiacovo - Fluconazole, 1996 30.510.01.0