Antimycotic Azoles (all routes except local only) - Medication and Pregnancy KB

Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Limb defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17739 R75015	Zhu - Fluconazole, 2020	Limb defects	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Fluconazole not specified or mixed dose	0.98 [0.85;1.13]	195/37,648 9,857/1,872,961	10,052	37,648		ref
S17833 R75266	Berard - Fluconazole, 2019	Musculoskeletal malformations	1st trimester	nested case control	unexposed (general population or NOS)	Adjustment: Yes Fluconazole not specified or mixed dose	1.16 [0.83;1.62]	58/1,313 8,223/224,031	8,281	1,313		ref
S17735 R74921	Molgaard-Nielsen - Fluconazole, 2013	Limb defects	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Fluconazole not specified or mixed dose	0.84 [0.57;1.23]	27/7,352 4,143/968,236	4,170	7,352		ref
S17745 R75031	Jick - Fluconazole and Itraconazole (Oral), 1999	Limb disorders (polydactyly, syndactyly, hip dislocation, talipes or others)	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	1.27 [0.27;5.99] ^C	2/322 8/1,629	10	322		ref
					Total	4 studies	0.99 [0.87;1.12]		22,513	46,635
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Oral;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded