Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17748
R75065		 De Santis - Itraconazole, 2009 Termination of pregnancy (TOP) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 2.90 [1.19;7.06] C 19/206   7/207 26 206
ref
S17747
R75052		 Bar-Oz - Itraconazole, 2000 Therapeutic abortions 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 16.06 [2.10;122.80] C 15/199   1/198 16 199
ref
S17733
R74841		 Mastroiacovo - Fluconazole, 1996 Induced abortion 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose Matched 5.06 [2.28;11.21] 29/226   9/452 38 226
ref
Total 3 studies 4.52 [2.31;8.84] 80 631
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Santis - Itraconazole, 2009De Santis - Itraconazole, 2009 2.90[1.19; 7.06]2620641%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Bar-Oz - Itraconazole, 2000Bar-Oz - Itraconazole, 2000 16.06[2.10; 122.80]1619910%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Mastroiacovo - Fluconazole, 1996Mastroiacovo - Fluconazole, 1996 5.06[2.28; 11.21]3822648%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 20% 4.52[2.31; 8.84]806310.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.52[2.31; 8.84]8063120%NADe Santis - Itraconazole, 2009 Bar-Oz - Itraconazole, 2000 Mastroiacovo - Fluconazole, 1996 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.52[2.31; 8.84]8063120%NADe Santis - Itraconazole, 2009 Bar-Oz - Itraconazole, 2000 Mastroiacovo - Fluconazole, 1996 3 Tags Adjustment   - No  - No 5.29[1.07; 26.22]4240556%NADe Santis - Itraconazole, 2009 Bar-Oz - Itraconazole, 2000 2   - Yes  - Yes 5.06[2.28; 11.22]38226 -NAMastroiacovo - Fluconazole, 1996 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 5.06[2.28; 11.22]38226 -NAMastroiacovo - Fluconazole, 1996 1 MatchedMatched 4.52[2.31; 8.84]8063120%NADe Santis - Itraconazole, 2009 Bar-Oz - Itraconazole, 2000 Mastroiacovo - Fluconazole, 1996 3 All studiesAll studies 4.52[2.31; 8.84]8063120%NADe Santis - Itraconazole, 2009 Bar-Oz - Itraconazole, 2000 Mastroiacovo - Fluconazole, 1996 30.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.52[2.31; 8.84]8063120%NADe Santis - Itraconazole, 2009 Bar-Oz - Itraconazole, 2000 Mastroiacovo - Fluconazole, 1996 30.510.01.0