Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17734
R74865		 Howley - Fluconazole, 2016 Esophageal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 5.13 [1.03;25.46] C 2/8   754/12,360 756 8
ref
Total 1 studies 5.13 [1.03;25.46] 756 8
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley - Fluconazole, 2016Howley - Fluconazole, 2016 5.13[1.03; 25.46]75680%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 5.13[1.03; 25.46]7568 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.13[1.03; 25.46]7568 -NAHowley - Fluconazole, 2016 1 Tags Adjustment   - No  - No 5.13[1.03; 25.46]7568 -NAHowley - Fluconazole, 2016 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 5.13[1.03; 25.46]7568 -NAHowley - Fluconazole, 2016 1 All studiesAll studies 5.13[1.03; 25.46]7568 -NAHowley - Fluconazole, 2016 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.13[1.03; 25.46]7568 -NAHowley - Fluconazole, 2016 10.510.01.0