Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17735
R74923		 Molgaard-Nielsen - Fluconazole, 2013 Polydactyly 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.06 [0.44;2.56] 5/7,352   592/968,236 597 7,352
ref
S17745
R75030		 Jick - Fluconazole and Itraconazole (Oral), 1999 Polydactyly or syndactyly 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.01 [0.12;8.69] C 1/322   5/1,629 6 322
ref
Total 2 studies 1.05 [0.47;2.38] 603 7,674
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Molgaard-Nielsen - Fluconazole, 2013Molgaard-Nielsen - Fluconazole, 2013 1.06[0.44; 2.56]5977,35286%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Jick - Fluconazole and Itraconazole (Oral), 1999Jick - Fluconazole and Itraco..., 1999 1 1.01[0.12; 8.69]632214%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.05[0.47; 2.38]6037,6740.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oral;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.47; 2.38]6037,6740%NAMolgaard-Nielsen - Fluconazole, 2013 Jick - Fluconazole and Itraconazole (Oral), 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.05[0.47; 2.38]6037,6740%NAMolgaard-Nielsen - Fluconazole, 2013 Jick - Fluconazole and Itraconazole (Oral), 1999 2 Tags Adjustment   - No  - No 1.01[0.12; 8.69]6322 -NAJick - Fluconazole and Itraconazole (Oral), 1999 1   - Yes  - Yes 1.06[0.44; 2.56]5977,352 -NAMolgaard-Nielsen - Fluconazole, 2013 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.06[0.44; 2.56]5977,352 -NAMolgaard-Nielsen - Fluconazole, 2013 1 All studiesAll studies 1.05[0.47; 2.38]6037,6740%NAMolgaard-Nielsen - Fluconazole, 2013 Jick - Fluconazole and Itraconazole (Oral), 1999 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.05[0.47; 2.38]6037,6740%NAMolgaard-Nielsen - Fluconazole, 2013 Jick - Fluconazole and Itraconazole (Oral), 1999 20.510.01.0