Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17734
R74872		 Howley - Fluconazole, 2016 Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 1.39 [0.22;7.13] 3/8   2,556/8,462 2,559 8
ref
S17725
R74796		 Carter - Miconazole, 2008 Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: No 0.47 [0.15;1.53] C 3/42   773/5,508 776 42
ref
Total 2 studies 0.66 [0.25;1.78] 3,335 50
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley - Fluconazole, 2016Howley - Fluconazole, 2016 1.39[0.22; 7.13]2,559832%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Carter - Miconazole, 2008Carter - Miconazole, 2008 0.47[0.15; 1.53]7764268%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 2% 0.66[0.25; 1.78]3,335500.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.66[0.25; 1.78]3,335502%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.66[0.25; 1.78]3,335502%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 2 Tags Adjustment   - No  - No 0.66[0.25; 1.78]3,335502%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.39[0.24; 7.91]2,5598 -NAHowley - Fluconazole, 2016 1 All studiesAll studies 0.66[0.25; 1.78]3,335502%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.66[0.25; 1.78]3,335502%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 20.510.01.0