Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Total anomalous pulm venous return

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R75004		 Zhu - Fluconazole, 2020 Pulmonary venous return 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 0.67 [0.30;1.51] -/37,648   443/1,872,961 - 37,648
ref
S17734
R74894		 Howley - Fluconazole, 2016 Total anomalous pulmonary venous return 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 2.95 [0.17;52.51] C 0/6   303/11,909 303 6
ref
Total 2 studies 0.75 [0.34;1.63] 303 37,654
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 0.67[0.30; 1.51]-37,64893%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Howley - Fluconazole, 2016Howley - Fluconazole, 2016 2.95[0.17; 52.51]30367%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.75[0.34; 1.63]30337,6540.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.67[0.30; 1.50]-37,648 -NAZhu - Fluconazole, 2020 1 case control studiescase control studies 2.95[0.17; 52.51]3036 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.75[0.34; 1.63]30337,6540%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 2 Tags Adjustment   - No  - No 2.95[0.17; 52.51]3036 -NAHowley - Fluconazole, 2016 1   - Yes  - Yes 0.67[0.30; 1.50]-37,648 -NAZhu - Fluconazole, 2020 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 0.75[0.34; 1.63]30337,6540%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 2 All studiesAll studies 0.75[0.34; 1.63]30337,6540%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.75[0.34; 1.63]73737,6540%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 20.510.01.0