Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Transposition of the great vessels

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R74991		 Zhu - Fluconazole, 2020 Transposition of great vessels 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.27 [0.81;2.01] 19/37,648   742/1,872,961 761 37,648
ref
S17734
R74889		 Howley - Fluconazole, 2016 D-transposition of the great arteries 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 7.56 [1.22;35.45] 3/9   768/12,374 771 9
ref
Total 2 studies 2.56 [0.46;14.10] 1,532 37,657
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 1.27[0.81; 2.01]76137,64861%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Howley - Fluconazole, 2016Howley - Fluconazole, 2016 7.56[1.22; 35.45]771939%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 75% 2.56[0.46; 14.10]1,53237,6570.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.27[0.81; 2.00]76137,648 -NAZhu - Fluconazole, 2020 1 case control studiescase control studies 7.56[1.40; 40.75]7719 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.56[0.46; 14.10]1,53237,65775%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 2 Tags Adjustment   - No  - No 7.56[1.40; 40.75]7719 -NAHowley - Fluconazole, 2016 1   - Yes  - Yes 1.27[0.81; 2.00]76137,648 -NAZhu - Fluconazole, 2020 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 2.56[0.46; 14.10]1,53237,65775%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 2 All studiesAll studies 2.56[0.46; 14.10]1,53237,65775%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.56[0.46; 14.10]1,53237,65775%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 20.510.01.0