Antimycotic Azoles (all routes except local only) - Medication and Pregnancy KB

Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Hypoplastic left heart (HLH/HLHS)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17734 R74895	Howley - Fluconazole, 2016	Hypoplastic left heart syndrome	1st trimester	case control	unexposed (general population or NOS)	Adjustment: No Fluconazole not specified or mixed dose	2.94 [0.35;24.42] ^C	1/7 659/12,265	660	7		ref
S17735 R74930	Molgaard-Nielsen - Fluconazole, 2013	Hypoplastic left heart	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Fluconazole not specified or mixed dose	2.03 [0.65;6.35]	3/7,352 184/968,236	187	7,352		ref
					Total	2 studies	2.21 [0.81;6.02]		847	7,359
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded