Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17734
R74851		 Howley - Fluconazole, 2016 Spina bifida 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 3.03 [0.61;15.05] C 2/8   1,275/12,881 1,277 8
ref
S17745
R75035		 Jick - Fluconazole and Itraconazole (Oral), 1999 Spina bifida 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.53 [0.23;28.03] C 1/322   2/1,629 3 322
ref
Total 2 studies 2.87 [0.76;10.88] 1,280 330
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley - Fluconazole, 2016Howley - Fluconazole, 2016 3.03[0.61; 15.05]1,277869%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Jick - Fluconazole and Itraconazole (Oral), 1999Jick - Fluconazole and Itraco..., 1999 1 2.53[0.23; 28.03]332231%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 2.87[0.76; 10.88]1,2803300.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oral;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.53[0.23; 28.03]3322 -NAJick - Fluconazole and Itraconazole (Oral), 1999 1 case control studiescase control studies 3.03[0.61; 15.05]1,2778 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.87[0.76; 10.88]1,2803300%NAHowley - Fluconazole, 2016 Jick - Fluconazole and Itraconazole (Oral), 1999 2 Tags Adjustment   - No  - No 2.87[0.76; 10.88]1,2803300%NAHowley - Fluconazole, 2016 Jick - Fluconazole and Itraconazole (Oral), 1999 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 3.03[0.61; 15.05]1,2778 -NAHowley - Fluconazole, 2016 1 All studiesAll studies 2.87[0.76; 10.88]1,2803300%NAHowley - Fluconazole, 2016 Jick - Fluconazole and Itraconazole (Oral), 1999 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.87[0.76; 10.88]1,2803300%NAHowley - Fluconazole, 2016 Jick - Fluconazole and Itraconazole (Oral), 1999 20.510.01.0