Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17734
R74868		 Howley - Fluconazole, 2016 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 3.60 [0.73;17.85] C 2/8   1,075/12,681 1,077 8
ref
S17725
R74795		 Carter - Miconazole, 2008 Anorectal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.77 [0.54;5.77] C 3/42   206/4,941 209 42
ref
Total 2 studies 2.27 [0.88;5.88] 1,286 50
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley - Fluconazole, 2016Howley - Fluconazole, 2016 3.60[0.73; 17.85]1,077835%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Carter - Miconazole, 2008Carter - Miconazole, 2008 1.77[0.54; 5.77]2094265%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.27[0.88; 5.88]1,286500.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.27[0.88; 5.88]1,286500%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.27[0.88; 5.88]1,286500%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 2 Tags Adjustment   - No  - No 2.27[0.88; 5.88]1,286500%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 3.60[0.73; 17.85]1,0778 -NAHowley - Fluconazole, 2016 1 All studiesAll studies 2.27[0.88; 5.88]1,286500%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.27[0.88; 5.88]1,286500%NAHowley - Fluconazole, 2016 Carter - Miconazole, 2008 20.510.01.0