Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R75009		 Zhu - Fluconazole, 2020 Ear defects 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 0.71 [0.32;1.58] -/37,648   422/1,872,961 - 37,648
ref
S17735
R74920		 Molgaard-Nielsen - Fluconazole, 2013 Middle-ear defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 4.54 [0.27;76.14] C 0/7,352   14/968,236 14 7,352
ref
Total 2 studies 1.08 [0.24;4.90] 14 45,000
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 0.71[0.32; 1.58]-37,64878%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Molgaard-Nielsen - Fluconazole, 2013Molgaard-Nielsen - Fluconazole, 2013 4.54[0.27; 76.14]147,35222%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 35% 1.08[0.24; 4.90]1445,0000.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.08[0.24; 4.90]1445,00035%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.08[0.24; 4.90]1445,00035%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 2 Tags Adjustment   - No  - No 4.54[0.27; 76.14]147,352 -NAMolgaard-Nielsen - Fluconazole, 2013 1   - Yes  - Yes 0.71[0.32; 1.58]-37,648 -NAZhu - Fluconazole, 2020 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.08[0.24; 4.90]1445,00035%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 2 All studiesAll studies 1.08[0.24; 4.90]1445,00035%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.24; 4.90]42745,00035%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 20.510.01.0