Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R74999		 Zhu - Fluconazole, 2020 Atrioventricular septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 0.83 [0.41;1.66] -/37,648   482/1,872,961 - 37,648
ref
S17734
R74893		 Howley - Fluconazole, 2016 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 5.21 [0.63;43.42] C 1/7   371/11,977 372 7
ref
Total 2 studies 1.57 [0.28;8.69] 372 37,655
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 0.83[0.41; 1.66]-37,64865%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Howley - Fluconazole, 2016Howley - Fluconazole, 2016 5.21[0.63; 43.42]372735%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 62% 1.57[0.28; 8.69]37237,6550.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.83[0.41; 1.67]-37,648 -NAZhu - Fluconazole, 2020 1 case control studiescase control studies 5.21[0.63; 43.42]3727 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.57[0.28; 8.69]37237,65562%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 2 Tags Adjustment   - No  - No 5.21[0.63; 43.42]3727 -NAHowley - Fluconazole, 2016 1   - Yes  - Yes 0.83[0.41; 1.67]-37,648 -NAZhu - Fluconazole, 2020 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.57[0.28; 8.69]37237,65562%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 2 All studiesAll studies 1.57[0.28; 8.69]37237,65562%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.57[0.28; 8.69]84537,65562%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 20.510.01.0