Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R74979		 Zhu - Fluconazole, 2020 Oral clefts 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 0.83 [0.60;1.16] 35/37,648   2,092/1,872,961 2,127 37,648
ref
S17745
R75032		 Jick - Fluconazole and Itraconazole (Oral), 1999 Cleft lip or palate 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.69 [0.07;41.52] C 0/322   1/1,629 1 322
ref
Total 2 studies 0.84 [0.60;1.16] 2,128 37,970
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 0.83[0.60; 1.16]2,12737,64899%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Jick - Fluconazole and Itraconazole (Oral), 1999Jick - Fluconazole and Itraco..., 1999 1 1.69[0.07; 41.52]13221%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.84[0.60; 1.16]2,12837,9700.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oral;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.84[0.60; 1.16]2,12837,9700%NAZhu - Fluconazole, 2020 Jick - Fluconazole and Itraconazole (Oral), 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.84[0.60; 1.16]2,12837,9700%NAZhu - Fluconazole, 2020 Jick - Fluconazole and Itraconazole (Oral), 1999 2 Tags Adjustment   - No  - No 1.69[0.07; 41.52]1322 -NAJick - Fluconazole and Itraconazole (Oral), 1999 1   - Yes  - Yes 0.83[0.60; 1.15]2,12737,648 -NAZhu - Fluconazole, 2020 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 0.83[0.60; 1.15]2,12737,648 -NAZhu - Fluconazole, 2020 1 All studiesAll studies 0.84[0.60; 1.16]2,12837,9700%NAZhu - Fluconazole, 2020 Jick - Fluconazole and Itraconazole (Oral), 1999 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.84[0.60; 1.16]2,12837,9700%NAZhu - Fluconazole, 2020 Jick - Fluconazole and Itraconazole (Oral), 1999 20.510.01.0