Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R75013		 Zhu - Fluconazole, 2020 Genital malformations 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.04 [0.90;1.21] 182/37,648   8,688/1,872,961 8,870 37,648
ref
S17833
R75264		 Berard - Fluconazole, 2019 Genital malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.98 [0.99;3.96] 13/1,313   1,166/225,286 1,179 1,313
ref
Total 2 studies 1.31 [0.71;2.39] 10,049 38,961
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 1.04[0.90; 1.21]8,87037,64864%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Berard - Fluconazole, 2019Berard - Fluconazole, 2019 1.98[0.99; 3.96]1,1791,31336%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 68% 1.31[0.71; 2.39]10,04938,9610.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.04[0.90; 1.21]8,87037,648 -NAZhu - Fluconazole, 2020 1 case control studiescase control studies 1.98[0.99; 3.96]1,1791,313 -NABerard - Fluconazole, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.31[0.71; 2.39]10,04938,96168%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 2 Tags Adjustment   - Yes  - Yes 1.31[0.71; 2.39]10,04938,96168%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.31[0.71; 2.39]10,04938,96168%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 2 All studiesAll studies 1.31[0.71; 2.39]10,04938,96168%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.31[0.71; 2.39]10,04938,96168%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 20.510.01.0