Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R75007		 Zhu - Fluconazole, 2020 Central Nervous System malformations 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.12 [0.91;1.37] 94/37,648   4,190/1,872,961 4,284 37,648
ref
S17833
R75260		 Berard - Fluconazole, 2019 Nervous malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.52 [0.67;3.46] 9/1,313   890/225,286 899 1,313
ref
Total 2 studies 1.14 [0.93;1.39] 5,183 38,961
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 1.12[0.91; 1.37]4,28437,64894%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Berard - Fluconazole, 2019Berard - Fluconazole, 2019 1.52[0.67; 3.46]8991,3136%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.14[0.93; 1.39]5,18338,9610.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.91; 1.37]4,28437,648 -NAZhu - Fluconazole, 2020 1 case control studiescase control studies 1.52[0.67; 3.45]8991,313 -NABerard - Fluconazole, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.14[0.93; 1.39]5,18338,9610%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 2 Tags Adjustment   - Yes  - Yes 1.14[0.93; 1.39]5,18338,9610%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.14[0.93; 1.39]5,18338,9610%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 2 All studiesAll studies 1.14[0.93; 1.39]5,18338,9610%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.14[0.93; 1.39]5,18338,9610%NAZhu - Fluconazole, 2020 Berard - Fluconazole, 2019 20.510.01.0