Azoles (local routes only) updated on 01-29-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.05 [1.01, 1.09]0%6 studies95,49486,412not evaluable ROB1.28 [1.14; .]
Congenital heart defects1.06 [0.99, 1.14]0%5 studies25,92385,124not evaluable ROB-
Cleft lip with or without cleft palate0.94 [0.68, 1.28]0%4 studies3,00084,606not evaluable ROB-
Major congenital malformations1.02 [0.92, 1.13]0%4 studies24,4573,236not evaluable ROB-
Limb defects1.06 [0.96, 1.17]0%3 studies9,70184,575not evaluable ROB-
Ano-rectal atresia and stenosis2.03 [0.38, 10.86]0%2 studies429106not evaluable ROB-
Cleft palate0.88 [0.65, 1.19]0%2 studies1,64382,590not evaluable ROB-
Ear malformations1.29 [0.88, 1.88]0%2 studies78682,590not evaluable ROB-
Gastroschisis1.31 [0.21, 8.40]0%2 studies658508not evaluable ROB-
Genital anomalies1.06 [0.95, 1.18]0%2 studies7,76582,590not evaluable ROB-
Hypospadias1.04 [0.66, 1.64]0%2 studies3,171541not evaluable ROB-
Nervous system anomalies1.04 [0.89, 1.20]0%2 studies4,57284,083not evaluable ROB-
Neural Tube Defects0.92 [0.48, 1.78]0%2 studies1,952254not evaluable ROB-
Oro-facial clefts0.91 [0.73, 1.13]0%2 studies2,29382,582not evaluable ROB-
Polydactyly1.21 [0.61, 2.38]0%2 studies1,3781,010not evaluable ROB-
Atrial septal defect0.99 [0.85, 1.17]-1 study3,69082,090not evaluable ROB-
Atrioventricular septal defect1.33 [0.89, 1.98]-1 study45682,090not evaluable ROB-
Bilateral renal agenesis including Potter syndrome0.61 [0.04, 9.82]-1 study54498not evaluable ROB-
Club foot / Talipes equinovarus1.14 [0.68, 1.92]-1 study2,009530not evaluable ROB-
Craniosynostosis3.06 [0.63, 14.78]-1 study4479not evaluable ROB-
Diaphragmatic hernia1.16 [0.07, 20.32]-1 study2757not evaluable ROB-
Digestive system anomalies1.30 [0.64, 2.63]-1 study3071,993not evaluable ROB-
Eye defects1.07 [0.77, 1.50]-1 study80282,090not evaluable ROB-
Hydrocephaly1.67 [0.27, 10.30]-1 study284503not evaluable ROB-
Limb reduction defects (LRD)1.03 [0.36, 2.97]-1 study448507not evaluable ROB-
Microcephaly / Small head circumference for gestational age0.30 [0.11, 0.85]-1 study10945not evaluable ROB6.12 [.; 1.64]
Oesophageal atresia with or without tracheo-oesophageal fistula7.00 [0.72, 68.48]-1 study217102not evaluable ROB-
Patent ductus arterious1.11 [0.89, 1.37]-1 study1,86282,090not evaluable ROB-
Respiratory system anomalies1.08 [0.93, 1.24]-1 study4,39982,090not evaluable ROB-
Spina bifida0.66 [0.03, 13.81]-1 study2492not evaluable ROB-
Tetralogy of Fallot1.43 [1.04, 1.96]-1 study69682,090not evaluable ROB2.21 [1.25; .]
Total anomalous pulm venous return0.93 [0.55, 1.55]-1 study38582,090not evaluable ROB-
Transposition of the great vessels0.80 [0.53, 1.19]-1 study74382,090not evaluable ROB-
Urinary malformations1.08 [0.95, 1.23]-1 study5,32482,090not evaluable ROB-
Ventricular septal defect1.10 [0.99, 1.22]-1 study7,88682,090not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.06 [0.96, 1.18]-1 study16,222not evaluable ROB-
Small for gestational age (weight)0.78 [0.66, 0.92]-1 study16,222not evaluable ROB1.88 [.; 1.39]

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Persistent pulmonary hypertension--0 study-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Leukemia0.94 [0.39, 2.25]-1 study24324not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)1.06 [0.94, 1.20]0%2 studies7,1846,069not evaluable ROB-
Late intrauterine deaths (> 22 weeks)1.43 [0.89, 2.30]-1 study994,301not evaluable ROB-

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