Azoles (local routes only) updated on 01-29-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17614
R74398		 Araujo - Sertaconazole (Topical), 2022 Preterm birth during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Route of exposure Azoles: Dermal/Topical 1.06 [0.95;1.17] -/16,222   -/91,976 - 16,222
ref
Total 1 studies 1.06 [0.96;1.18] 0 16,222
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Araujo - Sertaconazole (Topical), 2022Araujo - Sertaconazole, 2022 1 1.06[0.95; 1.17]-16,2220%ROB confusion: unclearROB selection: lowROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topical;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.96; 1.18]-16,222 -NAAraujo - Sertaconazole (Topical), 2022 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.96; 1.18]-16,222 -NAAraujo - Sertaconazole (Topical), 2022 1 Tags Adjustment   - Yes  - Yes 1.06[0.96; 1.18]-16,222 -NAAraujo - Sertaconazole (Topical), 2022 1 Route of exposure Azoles   - Dermal/Topical  - Dermal/Topical 1.06[0.96; 1.18]-16,222 -NAAraujo - Sertaconazole (Topical), 2022 1 All studiesAll studies 1.06[0.96; 1.18]-16,222 -NAAraujo - Sertaconazole (Topical), 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.96; 1.18]-16,222 -NAAraujo - Sertaconazole (Topical), 2022 10.510.01.0