Azoles (local routes only) updated on 01-29-2025

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10366
R38061		 Zhu - Azoles (Local routes), 2020 Respiratory malformations 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Route of exposure Azoles: Local (NOS) 1.08 [0.93;1.24] C 198/82,090   4,201/1,875,257 4,399 82,090
ref
Total 1 studies 1.08 [0.93;1.24] 4,399 82,090
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Azoles (Local routes), 2020Zhu - Azoles, 2020 1 1.08[0.93; 1.24]4,39982,0900%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Local routes;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.08[0.93; 1.24]4,39982,090 -NAZhu - Azoles (Local routes), 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.08[0.93; 1.24]4,39982,090 -NAZhu - Azoles (Local routes), 2020 1 Tags Adjustment   - No  - No 1.08[0.93; 1.24]4,39982,090 -NAZhu - Azoles (Local routes), 2020 1 Route of exposure Azoles   - Local (NOS)  - Local (NOS) 1.08[0.93; 1.24]4,39982,090 -NAZhu - Azoles (Local routes), 2020 1 All studiesAll studies 1.08[0.93; 1.24]4,39982,090 -NAZhu - Azoles (Local routes), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.93; 1.24]4,39982,090 -NAZhu - Azoles (Local routes), 2020 10.510.01.0