Azoles (local routes only) updated on 01-29-2025

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4260
R9868		 Jick - Azole (Topical route), 1999 Spina bifida 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Route of exposure Azoles: Local (NOS) 0.66 [0.03;13.81] C 0/492   2/1,629 2 492
ref
Total 1 studies 0.66 [0.03;13.81] 2 492
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jick - Azole (Topical route), 1999Jick - Azole, 1999 1 0.66[0.03; 13.81]24920%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topical route;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.66[0.03; 13.81]2492 -NAJick - Azole (Topical route), 1999 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.66[0.03; 13.81]2492 -NAJick - Azole (Topical route), 1999 1 Tags Adjustment   - No  - No 0.66[0.03; 13.81]2492 -NAJick - Azole (Topical route), 1999 1 Route of exposure Azoles   - Local (NOS)  - Local (NOS) 0.66[0.03; 13.81]2492 -NAJick - Azole (Topical route), 1999 1 All studiesAll studies 0.66[0.03; 13.81]2492 -NAJick - Azole (Topical route), 1999 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.66[0.03; 13.81]2492 -NAJick - Azole (Topical route), 1999 10.510.01.0