Azoles (local routes only) updated on 01-29-2025

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10388
R38156		 Molgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls exposed to pivmecillinam), 2016 Stillbirth (pregnancy loss from 23 weeks) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Route of exposure Azoles: Vaginal 2.48 [1.14;5.40] C
excluded (control group) 		22/4,301   9/4,357 31 4,301
ref
S10386
R38152		 Molgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 Stillbirth (pregnancy loss from 23 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Route of exposure Azoles: Vaginal 1.43 [0.89;2.30] C 22/4,301   77/21,506 99 4,301
ref
Total 1 studies 1.43 [0.89;2.30] 99 4,301
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Molgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016Molgaard-Nielsen - Clotrimazo..., 2016 1 1.43[0.89; 2.30]994,3010%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Vaginal) (Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.89; 2.30]994,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.43[0.89; 2.30]994,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 1 Tags Adjustment   - No  - No 1.43[0.89; 2.30]994,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 1 Route of exposure Azoles   - Vaginal  - Vaginal 1.43[0.89; 2.30]994,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 1 All studiesAll studies 1.43[0.89; 2.30]994,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10388

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[0.89; 2.30]994,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls unexposed, NOS), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.48[1.14; 5.40]314,301 -NAMolgaard-Nielsen - Clotrimazole/miconazole (Vaginal) (Controls exposed to pivmecillinam), 2016 10.510.01.0