Clonazepam (Epilepsy) updated on 02-10-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.55 [0.67, 3.56]0%13 studies297176low ROB-
Major congenital malformations1.58 [0.67, 3.77]0%11 studies292174probable ROB-
Congenital heart defects3.57 [0.68, 18.88]0%4 studies1915not evaluable ROB-
Hypospadias4.07 [0.53, 31.48]0%3 studies911not evaluable ROB-
Digestive system anomalies17.65 [1.85, 168.66]0%2 studies413not evaluable ROB34.80 [3.10; .]
Limb defects17.03 [1.82, 159.26]0%2 studies413not evaluable ROB33.56 [3.05; .]
Microcephaly / Small head circumference for gestational age1.23 [0.14, 10.66]30%2 studies708340not evaluable ROB-
Polydactyly4.27 [0.23, 78.33]0%2 studies22not evaluable ROB-
Minor congenital malformations6.10 [0.45, 82.29]0%2 studies57not evaluable ROB-
Nervous system anomalies97.00 [1.67, 5617.77]-1 study4not evaluable ROB193.50 [2.74; .]
Neural Tube Defects15.19 [1.13, 204.41]0%2 studies210not evaluable ROB29.87 [1.51; .]
5 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.71 [0.24, 12.03]0%2 studies8615not evaluable ROB-
Small for gestational age (weight)1.40 [1.03, 1.89]0%2 studies2,473340not evaluable ROB2.15 [1.22; .]
4 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
4 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)4.00 [0.85, 18.71]0%2 studies7113not evaluable ROB-
Neonatal medical care4.08 [1.09, 15.30]0%2 studies15513not evaluable ROB7.63 [1.40; .]
Low Apgar score (< 7) (at 5 min)54.08 [4.59, 637.79]-1 study45not evaluable ROB107.66 [8.64; .]
7 non statistically significant endpoints reported in only one study

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
1 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Perinatal death5.61 [0.54, 58.60]0%2 studies1020not evaluable ROB-
1 non statistically significant endpoints reported in only one study

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
7 non statistically significant endpoints reported in only one study

- About - Master protocol - Browse exposition - RSS - Made with in Lyon - Contact us - Privacy policy - Licence Creative Commons