Clonazepam (Epilepsy) updated on 02-10-2025

Neonatal medical care

id	Study   Auto Artama (Epilepsy) (Controls exposed to Lamotrigine, sick), 2013Artama (Epilepsy) (Controls unexposed, disease free), 2013Artama (Epilepsy) (Controls unexposed, sick), 2013D'Souza (Epilepsy) (Controls unexposed, disease free), 1991D'Souza (Epilepsy) (Controls unexposed, sick), 1991	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S5924 R15053	Artama (Epilepsy) (Controls exposed to Lamotrigine, sick), 2013	Admission to neonatal care unit	3rd trimester	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	1.81 [0.46;7.16] C excluded (control group)	3/12   24/154	27	12		ref
S5905 R14845	Artama (Epilepsy) (Controls unexposed, disease free), 2013	Admission to neonatal care unit	3rd trimester	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	4.52 [1.17;17.47] excluded (control group)	3/12   49,612/689,482	49,615	12		ref
S5916 R14964	Artama (Epilepsy) (Controls unexposed, sick), 2013	Admission to neonatal care unit	3rd trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes	3.68 [0.93;14.48]	3/12   152/1,708	155	12		ref
S6688 R18691	D'Souza (Epilepsy) (Controls unexposed, disease free), 1991	Idiopathic respiratory distress	throughout pregnancy	prospective cohort	unexposed, disease free excluded	Adjustment: No Matched	123.00 [1.00;15058.31] C excluded (control group)	0/1   0/62	0	1		ref
S6696 R18852	D'Souza (Epilepsy) (Controls unexposed, sick), 1991	Idiopathic respiratory distress	throughout pregnancy	prospective cohort	unexposed, sick	Adjustment: No	15.00 [0.12;1923.88] C	0/1   0/8	0	1		ref
					Total	2 studies	4.08 [1.09;15.30]		155	13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 6688, 5924, 5905