Clonazepam (Epilepsy) updated on 02-10-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5924
R15055		 Artama (Epilepsy) (Controls exposed to Lamotrigine, sick), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 10.75 [0.91;127.39] C
excluded (control group) 		1/5   3/132 4 5
ref
S5905
R14847		 Artama (Epilepsy) (Controls unexposed, disease free), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 24.51 [2.49;241.20]
excluded (control group) 		1/5   3,014/269,151 3,015 5
ref
S5916
R14966		 Artama (Epilepsy) (Controls unexposed, sick), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective unexposed, sick Adjustment: No 54.08 [4.59;637.79] C 1/5   3/652 4 5
ref
Total 1 studies 54.08 [4.59;637.79] 4 5
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Epilepsy) (Controls unexposed, sick), 2013Artama, 2013 1 54.08[4.59; 637.79]450%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.9500.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 54.08[4.59; 637.79]45 -NAArtama (Epilepsy) (Controls unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 54.08[4.59; 637.79]45 -NAArtama (Epilepsy) (Controls unexposed, sick), 2013 1 Tags Adjustment   - No  - No 54.08[4.59; 637.79]45 -NAArtama (Epilepsy) (Controls unexposed, sick), 2013 1 All studiesAll studies 54.08[4.59; 637.79]45 -NAArtama (Epilepsy) (Controls unexposed, sick), 2013 10.51000.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5924, 5905

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale24.51[2.49; 241.23]3,0155 -NAArtama (Epilepsy) (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls Out of scale54.08[4.59; 637.79]45 -NAArtama (Epilepsy) (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale10.75[0.91; 127.39]45 -NAArtama (Epilepsy) (Controls exposed to Lamotrigine, sick), 2013 10.510.01.0