Clonazepam (Epilepsy) updated on 02-10-2025

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12876
R48645		 Thomas (Epilepsy) (Controls exposed to Lamotrigine, sick), 2021 Neural malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 14.14 [0.24;825.80] C
excluded (control group) 		0/4   0/50 0 4
ref
S12877
R48655		 Thomas (Epilepsy) (Controls unexposed, sick), 2021 Neural malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 97.00 [1.67;5617.77] C 0/4   0/340 0 4
ref
Total 1 studies 97.00 [1.67;5617.77] 0 4
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas (Epilepsy) (Controls unexposed, sick), 2021Thomas, 2021 1 97.00[1.67; 5617.77]040%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.9500.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 97.00[1.67; 5617.77]-4 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 97.00[1.67; 5617.77]-4 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 97.00[1.67; 5617.77]-4 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 All studiesAll studies 97.00[1.67; 5617.77]-4 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 10.51000.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12876

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale97.00[1.67; 5617.77]-4 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale14.14[0.24; 825.80]-4 -NAThomas (Epilepsy) (Controls exposed to Lamotrigine, sick), 2021 10.510.01.0