Clonazepam (Epilepsy) updated on 02-10-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6494
R17794		 Bànhidy (Epilepsy), 2011 Neural tube defects throughout pregnancy case control unexposed, sick Adjustment: No Matched 6.33 [0.09;458.24] C 0/1   1/11 1 1
ref
S6067
R15783		 Morrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006 Neural tube defect 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 25.31 [0.96;666.98] C 0/9   1/647 1 9
ref
Total 2 studies 15.19 [1.13;204.41] 2 10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Epilepsy), 2011Bànhidy, 2011 1 6.33[0.09; 458.24]1137%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Morrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006Morrow, 2006 2 25.31[0.96; 666.98]1963%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 15.19[1.13; 204.41]2100.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy; 2: Epilepsy) (Controls exposed to Lamotrigine, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 25.31[0.96; 666.98]19 -NAMorrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006 1 case control studiescase control studies 6.33[0.09; 458.24]11 -NABànhidy (Epilepsy), 2011 1 Type of controls unexposed, sickunexposed, sick 6.33[0.09; 458.24]11 -NABànhidy (Epilepsy), 2011 1 exposed to other treatment, sickexposed to other treatment, sick 25.31[0.96; 666.98]19 -NAMorrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006 1 Tags Adjustment   - No  - No 15.19[1.13; 204.41]2100%NABànhidy (Epilepsy), 2011 Morrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006 2 MatchedMatched 6.33[0.09; 458.24]11 -NABànhidy (Epilepsy), 2011 1 All studiesAll studies 15.19[1.13; 204.41]2100%NABànhidy (Epilepsy), 2011 Morrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 6.33[0.09; 458.24]11 -NABànhidy (Epilepsy), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale25.31[0.96; 666.98]19 -NAMorrow (Epilepsy) (Controls exposed to Lamotrigine, sick), 2006 10.510.01.0