Clonazepam (Epilepsy) updated on 02-10-2025

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6494
R17802		 Bànhidy (Epilepsy), 2011 Poly/syndactyly throughout pregnancy case control unexposed, sick Adjustment: No Matched 2.11 [0.06;79.98] C 0/1   2/12 2 1
ref
S6688
R18669		 D'Souza (Epilepsy) (Controls unexposed, disease free), 1991 Extra digits throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 123.00 [1.00;15058.31] C
excluded (control group) 		0/1   0/62 0 1
ref
S6696
R18830		 D'Souza (Epilepsy) (Controls unexposed, sick), 1991 Extra digits throughout pregnancy prospective cohort unexposed, sick Adjustment: No 15.00 [0.12;1923.88] C 0/1   0/8 0 1
ref
Total 2 studies 4.27 [0.23;78.33] 2 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Epilepsy), 2011Bànhidy, 2011 1 2.11[0.06; 79.98]2164%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate D'Souza (Epilepsy) (Controls unexposed, sick), 1991D'Souza, 1991 2 15.00[0.12; 1923.88]0136%ROB confusion: criticalROB selection: unclearROB classification: lowROB missing: unclearROB mesure: lowROB reporting: moderate Total (2 studies) I2 = 0% 4.27[0.23; 78.33]220.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy; 2: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 15.00[0.12; 1923.88]-1 -NAD'Souza (Epilepsy) (Controls unexposed, sick), 1991 1 case control studiescase control studies 2.11[0.06; 79.98]21 -NABànhidy (Epilepsy), 2011 1 Type of controls unexposed, sickunexposed, sick 4.27[0.23; 78.33]220%NABànhidy (Epilepsy), 2011 D'Souza (Epilepsy) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 4.27[0.23; 78.33]220%NABànhidy (Epilepsy), 2011 D'Souza (Epilepsy) (Controls unexposed, sick), 1991 2 MatchedMatched 2.11[0.06; 79.98]21 -NABànhidy (Epilepsy), 2011 1 All studiesAll studies 4.27[0.23; 78.33]220%NABànhidy (Epilepsy), 2011 D'Souza (Epilepsy) (Controls unexposed, sick), 1991 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6688

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale123.00[1.00; 15058.31]-1 -NAD'Souza (Epilepsy) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 4.27[0.23; 78.33]220%NABànhidy (Epilepsy), 2011 D'Souza (Epilepsy) (Controls unexposed, sick), 1991 20.510.01.0