metaPreg - Omeprazole during pregnancy

Omeprazole

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.05 [0.89, 1.24]	0%	7 studies	28,554	4,084	not evaluable	ROB	-
Major congenital malformations	1.09 [0.91, 1.31]	0%	5 studies	28,472	3,082	not evaluable	ROB	-
Hypospadias	1.69 [0.86, 3.34]	0%	4 studies	1,539	2,211	not evaluable	ROB	-
Congenital hydronephrosis	0.90 [0.35, 2.30]	0%	3 studies	3	2,201	not evaluable	ROB	-
Cleft lip with or without cleft palate	0.82 [0.15, 4.34]	20%	2 studies	1	1,939	not evaluable	ROB	-
Cleft palate	1.42 [0.26, 7.72]	0%	2 studies	1	1,939	not evaluable	ROB	-
Club foot / Talipes equinovarus	1.05 [0.36, 3.07]	0%	2 studies	3	1,939	not evaluable	ROB	-
Congenital heart defects	1.39 [0.45, 4.34]	53%	2 studies	5,436	1,802	not evaluable	ROB	-
Down syndrom / Trisomy 21	4.24 [0.35, 50.76]	0%	2 studies	1	401	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	0.98 [0.33, 2.96]	0%	2 studies	138	108	not evaluable	ROB	-
Syndactyly	1.56 [0.10, 25.51]	44%	2 studies		1,939	not evaluable	ROB	-
Atrial septal defect	0.95 [0.44, 2.04]	0%	2 studies		2,062	not evaluable	ROB	-
Bilateral renal agenesis including Potter syndrome	3.79 [0.15, 93.41]	-	1 study	1	139	not evaluable	ROB	-
Cardiac septal defects	7.65 [1.27, 46.17]	-	1 study	5	139	not evaluable	ROB	14.78 [1.85; .]
Eye defects	2.27 [0.11, 47.54]	-	1 study	2	139	not evaluable	ROB	-
Genetic syndromes and microdeletions	1.26 [0.07, 23.52]	-	1 study	4	139	not evaluable	ROB	-
Limb defects	0.87 [0.11, 6.71]	-	1 study	14	139	not evaluable	ROB	-
Nervous system anomalies	2.27 [0.11, 47.54]	-	1 study	2	139	not evaluable	ROB	-
Polydactyly	1.26 [0.07, 23.52]	-	1 study	4	139	not evaluable	ROB	-
Ventricular septal defect	1.19 [0.47, 2.98]	7%	2 studies	3	2,062	not evaluable	ROB	-
Encephalocele	0.24 [0.01, 5.96]	-	1 study	1	262	not evaluable	ROB	-
Patent ductus arterious	2.19 [0.09, 54.15]	-	1 study	1	262	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.28 [0.91, 1.78]	0%	3 studies	263	451	not evaluable	ROB	-
Low birth weight (< 2500g)	1.02 [0.89, 1.18]	0%	2 studies	104,260	3,372	not evaluable	ROB	-
Small for gestational age (weight)	0.55 [0.03, 9.17]	-	1 study	21	39	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	0.97 [0.48, 1.98]	-	1 study	38	91	not evaluable	ROB	-
Preeclampsia	1.10 [0.48, 2.51]	-	1 study	235	170	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low Apgar score (< 7) (at 5 min)	-	-	0 study					-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.37 [0.89, 2.11]	0%	2 studies	107	409	not evaluable	ROB	-
Late intrauterine deaths (> 22 weeks)	1.62 [0.15, 17.97]	54%	2 studies	20	435	not evaluable	ROB	-
Therapeutic terminations of pregnancy	1.21 [0.36, 4.09]	-	1 study	11	113	not evaluable	ROB	-
Ectopic pregnancy	-	-	0 study					-
Elective/induced termination of pregnancy	3.00 [1.72, 5.23]	-	1 study	53	296	not evaluable	ROB	5.45 [2.83; .]
Perinatal death	1.66 [0.70, 3.96]	-	1 study		863	not evaluable	ROB	-
Hide endpoints reported in only one study ...