Omeprazole

Syndactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4408
R10716		 Pasternak, 2010 Syndactyly 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.56 [0.07;4.33] 1/1,800   -/- - 1,800
ref
S4878
R12824		 Ruigomez (Controls exposed to other treatment, sick), 1999 Syndactyly 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.36 [0.06;33.59] C
excluded (control group) 		0/139   1/567 1 139
ref
S4877
R12777		 Ruigomez (Controls unexposed NOS), 1999 Syndactyly 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 11.37 [0.22;575.17] C 0/139   0/1,575 0 139
ref
Total 2 studies 1.56 [0.10;25.51] 0 1,939
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pasternak, 2010Pasternak, 2010 0.56[0.07; 4.33]-1,80066%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 11.37[0.22; 575.17]013934%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 44% 1.56[0.10; 25.51]-1,9390.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.56[0.10; 25.51]-1,93944%NAPasternak, 2010 Ruigomez (Controls unexposed NOS), 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.56[0.10; 25.51]-1,93944%NAPasternak, 2010 Ruigomez (Controls unexposed NOS), 1999 2 Tags Adjustment   - No  - No 11.37[0.22; 575.17]-139 -NARuigomez (Controls unexposed NOS), 1999 1   - Yes  - Yes 0.56[0.07; 4.40]-1,800 -NAPasternak, 2010 1 All studiesAll studies 1.56[0.10; 25.51]-1,93944%NAPasternak, 2010 Ruigomez (Controls unexposed NOS), 1999 20.250.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.56[0.10; 25.51]-1,93944%NAPasternak, 2010 Ruigomez (Controls unexposed NOS), 1999 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.36[0.06; 33.59]1139 -NARuigomez (Controls exposed to other treatment, sick), 1999 10.510.01.0