Omeprazole

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4517
R10876		 Diav-Citrin, 2005 Miscarriage during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.23 [0.75;2.02] C 24/296   58/868 82 296
ref
S4591
R11082		 Lalkin (Controls exposed to other treatment, sick), 1998 Spontaneous abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched 1.91 [0.80;4.51] C
excluded (control group) 		16/113   9/113 25 113
ref
S4594
R11097		 Lalkin (Controls unexposed NOS), 1998 Spontaneous abortion during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched 1.91 [0.80;4.51] C 16/113   9/113 25 113
ref
Total 2 studies 1.37 [0.89;2.11] 107 409
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Diav-Citrin, 2005Diav-Citrin, 2005 1.23[0.75; 2.02]8229675%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Lalkin (Controls unexposed NOS), 1998Lalkin, 1998 1 1.91[0.80; 4.51]2511325%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.37[0.89; 2.11]1074090.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.37[0.89; 2.11]1074090%NADiav-Citrin, 2005 Lalkin (Controls unexposed NOS), 1998 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.37[0.89; 2.11]1074090%NADiav-Citrin, 2005 Lalkin (Controls unexposed NOS), 1998 2 Tags Adjustment   - No  - No 1.37[0.89; 2.11]1074090%NADiav-Citrin, 2005 Lalkin (Controls unexposed NOS), 1998 2 MatchedMatched 1.91[0.80; 4.51]25113 -NALalkin (Controls unexposed NOS), 1998 1 All studiesAll studies 1.37[0.89; 2.11]1074090%NADiav-Citrin, 2005 Lalkin (Controls unexposed NOS), 1998 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4591

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.37[0.89; 2.11]1074090%NADiav-Citrin, 2005 Lalkin (Controls unexposed NOS), 1998 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.91[0.80; 4.51]25113 -NALalkin (Controls exposed to other treatment, sick), 1998 10.510.01.0