Omeprazole

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4480
R10724		 Kerr, 2018 Isolated microcephaly (ICD-9 - within 6 months after delivery) 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.53 [0.09;24.96] C 0/69   57/12,047 57 69
ref
S4878
R12830		 Ruigomez (Controls exposed to other treatment, sick), 1999 Small head circumference for gestational age (head circumference < 3rd percentile) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.76 [0.20;2.87] C
excluded (control group) 		3/39   11/111 14 39
ref
S4877
R12783		 Ruigomez (Controls unexposed NOS), 1999 Small head circumference for gestational age (head circumference < 3rd percentile) 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 0.90 [0.27;3.00] C 3/39   78/924 81 39
ref
Total 2 studies 0.98 [0.33;2.96] 138 108
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kerr, 2018Kerr, 2018 1.53[0.09; 24.96]576916%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 0.90[0.27; 3.00]813984%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.98[0.33; 2.96]1381080.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.27; 3.00]8139 -NARuigomez (Controls unexposed NOS), 1999 1 case control studiescase control studies 1.53[0.09; 24.96]5769 -NAKerr, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.98[0.33; 2.96]1381080%NAKerr, 2018 Ruigomez (Controls unexposed NOS), 1999 2 Tags Adjustment   - No  - No 0.98[0.33; 2.96]1381080%NAKerr, 2018 Ruigomez (Controls unexposed NOS), 1999 2 All studiesAll studies 0.98[0.33; 2.96]1381080%NAKerr, 2018 Ruigomez (Controls unexposed NOS), 1999 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.98[0.33; 2.96]1381080%NAKerr, 2018 Ruigomez (Controls unexposed NOS), 1999 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.76[0.20; 2.87]1439 -NARuigomez (Controls exposed to other treatment, sick), 1999 10.510.01.0