id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S4447 R13163 |
Matok, 2012 | Major malformations (according to CDC definitions) | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.11 [0.87;1.43] | 67/955 6,438/109,828 | 6,505 | 955 |
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S4669 R35112 |
Bànhidy, 2011 | Congenital abnormalities | during pregnancy (anytime or not specified) excluded | case control | unexposed (general population or NOS) | Adjustment: No Matched |
1.23 [1.02;1.47] C excluded (exposition period) |
206/487 22,637/60,507 | 22,843 | 487 |
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S4408 R13165 |
Pasternak, 2010 | Major birth defects (Exposure during First Trimester) | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes | 1.05 [0.79;1.40] | 52/1,800 21,867/837,317 | 21,919 | 1,800 |
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S4517 R28445 |
Diav-Citrin, 2005 | Major anomalies | 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: No | 1.09 [0.49;2.42] C | 8/194 30/792 | 38 | 194 |
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S4548 R10997 |
Källén, 2001 | Congenital malformations (ICD9 - ICD10) | at least 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes | 0.82 [0.50;1.34] | 22/863 -/- | 13 | 863 |
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S8548 R28405 |
Moretti, 2001 | Major malformations | at least 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: No | 1.36 [0.20;9.38] | 2/55 2/75 | 4 | 55 |
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S4878 R12784 |
Ruigomez (Controls exposed to other treatment, sick), 1999 | Malformations (minor and major) | 1st trimester | retrospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.65 [0.25;1.69] C excluded (control group) |
5/139 31/567 | 36 | 139 |
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S4877 R12737 |
Ruigomez (Controls unexposed NOS), 1999 | Malformations (minor and major) | 1st trimester | retrospective cohort | unexposed (general population or NOS) | Adjustment: Yes | 0.90 [0.40;2.40] | 5/139 64/1,575 | 69 | 139 |
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S4591 R13161 |
Lalkin (Controls exposed to other treatment, sick), 1998 | Major malformations | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No Matched |
1.71 [0.37;7.89] C excluded (control group) |
4/78 3/98 | 7 | 78 |
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S4594 R13162 |
Lalkin (Controls unexposed NOS), 1998 | Major malformations | 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: No Matched | 1.73 [0.31;9.76] C | 4/78 2/66 | 6 | 78 |
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Total | 7 studies | 1.05 [0.89;1.24] | 28,554 | 4,084 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed NOS; 2: Controls unexposed NOS;
Asymetry test p-value = 0.9549 (by Egger's regression)
slope=0.0443 (0.0860); intercept=0.0227 (0.3822); t=0.0595; p=0.9549
excluded 4591, 4878