Omeprazole

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4517
R10874		 Diav-Citrin, 2005 Preterm birth (< 37 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.38 [0.90;2.11] C 35/228   86/741 121 228
ref
S4878
R12823		 Ruigomez (Controls exposed to other treatment, sick), 1999 Preterm offspring (<37 weeks) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.05 [0.53;2.09] C
excluded (control group) 		11/139   43/567 54 139
ref
S4877
R12776		 Ruigomez (Controls unexposed NOS), 1999 Preterm offspring (<37 weeks) 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 1.09 [0.57;2.08] C 11/139   115/1,575 126 139
ref
S4591
R11080		 Lalkin (Controls exposed to other treatment, sick), 1998 Preterm (< 37 weeks) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched 0.56 [0.23;1.38] C
excluded (control group) 		8/84   16/101 24 84
ref
S4594
R11095		 Lalkin (Controls unexposed NOS), 1998 Preterm (< 37 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched 1.20 [0.43;3.34] C 8/84   8/99 16 84
ref
Total 3 studies 1.28 [0.91;1.78] 263 451
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Diav-Citrin, 2005Diav-Citrin, 2005 1.38[0.90; 2.11]12122862%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 1.09[0.57; 2.08]12613927%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Lalkin (Controls unexposed NOS), 1998Lalkin, 1998 2 1.20[0.43; 3.34]168411%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.28[0.91; 1.78]2634510.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS; 2: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.91; 1.78]2634510%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 Lalkin (Controls unexposed NOS), 1998 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.28[0.91; 1.78]2634510%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 Lalkin (Controls unexposed NOS), 1998 3 Tags Adjustment   - No  - No 1.28[0.91; 1.78]2634510%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 Lalkin (Controls unexposed NOS), 1998 3 MatchedMatched 1.20[0.43; 3.34]1684 -NALalkin (Controls unexposed NOS), 1998 1 All studiesAll studies 1.28[0.91; 1.78]2634510%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 Lalkin (Controls unexposed NOS), 1998 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4591, 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[0.91; 1.78]2634510%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 Lalkin (Controls unexposed NOS), 1998 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.82[0.45; 1.49]7822315%NARuigomez (Controls exposed to other treatment, sick), 1999 Lalkin (Controls exposed to other treatment, sick), 1998 20.510.01.0