Omeprazole

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4408
R10708		 Pasternak, 2010 Ventricular septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.02 [0.47;2.21] 7/1,800   -/- - 1,800
ref
S4554
R11023		 Källèn (Controls exposed to other treatment, sick), 1998 Ventricular septum defect 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 5.16 [0.26;100.47] C 3/262   0/191 3 262
ref
Total 2 studies 1.19 [0.47;2.98] 3 2,062
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pasternak, 2010Pasternak, 2010 1.02[0.47; 2.21]-1,80091%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Källèn (Controls exposed to other treatment, sick), 1998Källèn, 1998 1 5.16[0.26; 100.47]32629%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 7% 1.19[0.47; 2.98]32,0620.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to other treatment, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.19[0.47; 2.98]32,0627%NAPasternak, 2010 Källèn (Controls exposed to other treatment, sick), 1998 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.02[0.47; 2.21]-1,800 -NAPasternak, 2010 1 exposed to other treatment, sickexposed to other treatment, sick 5.16[0.26; 100.47]3262 -NAKällèn (Controls exposed to other treatment, sick), 1998 1 Tags Adjustment   - No  - No 5.16[0.26; 100.47]3262 -NAKällèn (Controls exposed to other treatment, sick), 1998 1   - Yes  - Yes 1.02[0.47; 2.21]-1,800 -NAPasternak, 2010 1 All studiesAll studies 1.19[0.47; 2.98]32,0627%NAPasternak, 2010 Källèn (Controls exposed to other treatment, sick), 1998 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.02[0.47; 2.21]-1,800 -NAPasternak, 2010 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.16[0.26; 100.47]3262 -NAKällèn (Controls exposed to other treatment, sick), 1998 10.510.01.0