Omeprazole

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4878
R12794		 Ruigomez (Controls exposed to other treatment, sick), 1999 Cardiac septal defects 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 8.26 [0.74;91.79] C
excluded (control group) 		2/139   1/567 3 139
ref
S4877
R12747		 Ruigomez (Controls unexposed NOS), 1999 Cardiac septal defects 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 7.65 [1.27;46.17] C 2/139   3/1,575 5 139
ref
Total 1 studies 7.65 [1.27;46.17] 5 139
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 7.65[1.27; 46.17]51390%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.65[1.27; 46.17]5139 -NARuigomez (Controls unexposed NOS), 1999 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.65[1.27; 46.17]5139 -NARuigomez (Controls unexposed NOS), 1999 1 Tags Adjustment   - No  - No 7.65[1.27; 46.17]5139 -NARuigomez (Controls unexposed NOS), 1999 1 All studiesAll studies 7.65[1.27; 46.17]5139 -NARuigomez (Controls unexposed NOS), 1999 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 7.65[1.27; 46.17]5139 -NARuigomez (Controls unexposed NOS), 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.26[0.74; 91.79]3139 -NARuigomez (Controls exposed to other treatment, sick), 1999 10.510.01.0