Omeprazole

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4517
R10870		 Diav-Citrin, 2005 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 4.43 [0.74;26.66] C 3/296   2/868 5 296
ref
S4878
R12822		 Ruigomez (Controls exposed to other treatment, sick), 1999 Stillbirths 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.37 [0.02;6.71] C
excluded (control group) 		0/139   5/567 5 139
ref
S4877
R12775		 Ruigomez (Controls unexposed NOS), 1999 Stillbirths 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 0.36 [0.02;6.10] C 0/139   15/1,575 15 139
ref
Total 2 studies 1.62 [0.15;17.97] 20 435
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Diav-Citrin, 2005Diav-Citrin, 2005 4.43[0.74; 26.66]529660%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 0.36[0.02; 6.10]1513940%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 54% 1.62[0.15; 17.97]204350.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.62[0.15; 17.97]2043554%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.62[0.15; 17.97]2043554%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 2 Tags Adjustment   - No  - No 1.62[0.15; 17.97]2043554%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 2 All studiesAll studies 1.62[0.15; 17.97]2043554%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.62[0.15; 17.97]2043554%NADiav-Citrin, 2005 Ruigomez (Controls unexposed NOS), 1999 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.37[0.02; 6.71]5139 -NARuigomez (Controls exposed to other treatment, sick), 1999 10.510.01.0