Omeprazole

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15113
R62075		 Choi, 2023 Low birth weight (perinatal weight <2.5 kg) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.02 [0.88;1.17] 204/3,372   104,056/2,121,323 104,260 3,372
ref
S4548
R10999		 Källén, 2001 Low birth weight (< 2500g) 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.20 [0.49;2.91] -/-   -/- - -
ref
Total 2 studies 1.02 [0.89;1.18] 104,260 3,372
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi, 2023Choi, 2023 1.02[0.88; 1.17]104,2603,37298%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Källén, 2001Källén, 2001 1.20[0.49; 2.91]--2%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.02[0.89; 1.18]104,2603,3720.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.02[0.89; 1.18]104,2603,3720%NAChoi, 2023 Källén, 2001 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.49; 2.92]-- -NAKällén, 2001 1 unexposed, sickunexposed, sick 1.02[0.88; 1.18]104,2603,372 -NAChoi, 2023 1 Tags Adjustment   - No  - No 1.20[0.49; 2.92]-- -NAKällén, 2001 1   - Yes  - Yes 1.02[0.88; 1.18]104,2603,372 -NAChoi, 2023 1 All studiesAll studies 1.02[0.89; 1.18]104,2603,3720%NAChoi, 2023 Källén, 2001 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.49; 2.92]-- -NAKällén, 2001 1 unexposed, sick controlsunexposed, sick controls 1.02[0.88; 1.18]104,2603,372 -NAChoi, 2023 10.510.01.0