Omeprazole

Down syndrom / Trisomy 21

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4878
R12828		 Ruigomez (Controls exposed to other treatment, sick), 1999 Down's syndrom 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.36 [0.06;33.59] C
excluded (control group) 		0/139   1/567 1 139
ref
S4877
R12781		 Ruigomez (Controls unexposed NOS), 1999 Down's syndrom 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 11.37 [0.22;575.17] C 0/139   0/1,575 0 139
ref
S4554
R11027		 Källèn (Controls exposed to other treatment, sick), 1998 Down's syndrome 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 2.19 [0.09;54.15] C 1/262   0/191 1 262
ref
Total 2 studies 4.24 [0.35;50.76] 1 401
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 11.37[0.22; 575.17]013940%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Källèn (Controls exposed to other treatment, sick), 1998Källèn, 1998 2 2.19[0.09; 54.15]126260%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 4.24[0.35; 50.76]14010.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS; 2: Controls exposed to other treatment, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.24[0.35; 50.76]14010%NARuigomez (Controls unexposed NOS), 1999 Källèn (Controls exposed to other treatment, sick), 1998 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 11.37[0.22; 575.17]-139 -NARuigomez (Controls unexposed NOS), 1999 1 exposed to other treatment, sickexposed to other treatment, sick 2.19[0.09; 54.15]1262 -NAKällèn (Controls exposed to other treatment, sick), 1998 1 Tags Adjustment   - No  - No 4.24[0.35; 50.76]14010%NARuigomez (Controls unexposed NOS), 1999 Källèn (Controls exposed to other treatment, sick), 1998 2 All studiesAll studies 4.24[0.35; 50.76]14010%NARuigomez (Controls unexposed NOS), 1999 Källèn (Controls exposed to other treatment, sick), 1998 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale11.37[0.22; 575.17]-139 -NARuigomez (Controls unexposed NOS), 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.73[0.18; 16.68]24010%NARuigomez (Controls exposed to other treatment, sick), 1999 Källèn (Controls exposed to other treatment, sick), 1998 20.510.01.0