metaPreg - Azoles (local routes only) during pregnancy

Azoles (local routes only) updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.05 [1.01, 1.09]	0%	6 studies	95,494	86,412	not evaluable	ROB	1.28 [1.14; .]
Congenital heart defects	1.06 [0.99, 1.14]	0%	5 studies	25,923	85,124	not evaluable	ROB	-
Cleft lip with or without cleft palate	0.94 [0.68, 1.28]	0%	4 studies	3,000	84,606	not evaluable	ROB	-
Major congenital malformations	1.02 [0.92, 1.13]	0%	4 studies	24,457	3,236	not evaluable	ROB	-
Limb defects	1.06 [0.96, 1.17]	0%	3 studies	9,701	84,575	not evaluable	ROB	-
Ano-rectal atresia and stenosis	2.03 [0.38, 10.86]	0%	2 studies	429	106	not evaluable	ROB	-
Cleft palate	0.88 [0.65, 1.19]	0%	2 studies	1,643	82,590	not evaluable	ROB	-
Ear malformations	1.29 [0.88, 1.88]	0%	2 studies	786	82,590	not evaluable	ROB	-
Gastroschisis	1.31 [0.21, 8.40]	0%	2 studies	658	508	not evaluable	ROB	-
Genital anomalies	1.06 [0.95, 1.18]	0%	2 studies	7,765	82,590	not evaluable	ROB	-
Hypospadias	1.04 [0.66, 1.64]	0%	2 studies	3,171	541	not evaluable	ROB	-
Nervous system anomalies	1.04 [0.89, 1.20]	0%	2 studies	4,572	84,083	not evaluable	ROB	-
Neural Tube Defects	0.92 [0.48, 1.78]	0%	2 studies	1,952	254	not evaluable	ROB	-
Oro-facial clefts	0.91 [0.73, 1.13]	0%	2 studies	2,293	82,582	not evaluable	ROB	-
Polydactyly	1.21 [0.61, 2.38]	0%	2 studies	1,378	1,010	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	0.30 [0.11, 0.85]	-	1 study	109	45	not evaluable	ROB	6.12 [.; 1.64]
Tetralogy of Fallot	1.43 [1.04, 1.96]	-	1 study	696	82,090	not evaluable	ROB	2.21 [1.25; .]
18 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Small for gestational age (weight)	0.78 [0.66, 0.92]	-	1 study		16,222	not evaluable	ROB	1.88 [.; 1.39]
1 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Persistent pulmonary hypertension	-	-	0 study					-
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.06 [0.94, 1.20]	0%	2 studies	7,184	6,069	not evaluable	ROB	-
1 non statistically significant endpoints reported in only one study