Azoles (local routes only)

Study	Exclusion reasons	Rmk	Reference
Rotem - Miconazole (Vaginal), 2018	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: 2 local azoles were assessed in this study using the same database: to avoid redundancy of controls, only 1 was used, this one with more exposed pregnancies (i.e Clotrimazole).	Rotem BJOG 2018; 125:1550-1556 10.1111/1471-0528.15293
Czeizel - Econazole (Vaginal), 2003	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: Database analyzing several local azoles => to avoid redundancy of cases and controls, only 1 substance was reported here, this one with the most exposed cases.	Czeizel Eur. J. Obstet. Gynecol. Reprod. Biol. 2003; 111:135-40 10.1016/s0301-2115(03)00192-1
Vermes - Clotrimazole, 2015	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: Study analysis several local azoles => to avoid redundancy of cases and controls, only 1 substance was reported here, this one with the most exposed cases, Kazy 2005b.	Vermes Birth Defects Res. Part A Clin. Mol. Teratol. 2015; 103:804-13 10.1002/bdra.23383
Czeizel - Miconazole (Topical), 2004	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: This database (HCCSCA) was used several times to assess local azole (Czeizel 2004, Czeizezl 1999, Kazy 2005)...: to avoid redundancy of cases and controls, only 1 was used, this one with more exposed cases.	Czeizel Congenit Anom (Kyoto) 2004; 44:41-5 10.1111/j.1741-4520.2004.00007.x
Kazy c - Metronidazole and miconazole (Vaginal), 2005	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: This database (HCCSCA) was used several times to assess local azole (Czeizel 2004, Czeizezl 1999, Kazy 2005)...: to avoid redundancy of cases and controls, only 1 was used, this one with more exposed cases.	Kazy Reprod Toxicol 2005; 20:89-94 10.1016/j.reprotox.2004.11.012