metaPreg - Hydroxychloroquine (All indications except Antiphospholipid Syndrom) during pregnancy

Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.27 [1.02, 1.59]	10%	15 studies	60,004	3,373	low	ROB	1.86 [1.15; .]
Major congenital malformations	1.26 [1.01, 1.58]	11%	11 studies	59,970	3,296	low	ROB	1.83 [1.08; .]
Congenital heart defects	1.37 [0.75, 2.49]	0%	3 studies	292	2,265	not evaluable	ROB	-
Digestive system anomalies	0.89 [0.45, 1.77]	0%	2 studies	111	2,239	not evaluable	ROB	-
Genital anomalies	2.60 [0.30, 22.70]	50%	2 studies	136	2,239	not evaluable	ROB	-
Limb defects	1.21 [0.64, 2.30]	0%	2 studies	106	2,239	not evaluable	ROB	-
Oro-facial clefts	3.70 [1.55, 8.83]	-	1 study	16	2,045	not evaluable	ROB	6.86 [2.48; .]
Urinary malformations	0.98 [0.10, 10.01]	61%	2 studies	92	2,239	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	1.85 [1.07, 3.20]	-	1 study	70	212	not evaluable	ROB	3.10 [1.34; .]
Cleft palate	-	-	0 study					-
Hypospadias	-	-	0 study					-
6 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	0.94 [0.72, 1.24]	65%	25 studies	31,251	1,913	probable	ROB	-
Small for gestational age (weight)	0.88 [0.67, 1.17]	40%	19 studies	23,616	1,467	low	ROB	-
Low birth weight (< 2500g)	0.93 [0.53, 1.61]	43%	5 studies	11,757	347	not evaluable	ROB	-
Very preterm (28 to 32 weeks)	0.37 [0.14, 0.92]	0%	3 studies	26	131	not evaluable	ROB	4.92 [.; 1.38]
3 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preeclampsia	0.47 [0.28, 0.77]	49%	16 studies	197	710	critical	ROB	3.71 [.; 1.94]
Caesarean	0.91 [0.64, 1.29]	4%	4 studies	278	283	not evaluable	ROB	-
Gestational diabetes	0.94 [0.57, 1.55]	6%	3 studies	10	141	not evaluable	ROB	-
Assisted deliveries (forceps, vacuum, ...)	1.05 [0.52, 2.13]	0%	2 studies	35	186	not evaluable	ROB	-
Maternal death	1.43 [0.18, 11.45]	0%	2 studies	3	88	not evaluable	ROB	-
Oligohydramnios	0.54 [0.15, 1.96]	0%	2 studies	15	118	not evaluable	ROB	-
Postpartum hemorrhage	2.19 [0.34, 14.03]	42%	2 studies	23	65	not evaluable	ROB	-
3 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Eye deficiency / Visual abnormality	1.19 [0.16, 8.63]	0%	4 studies		205	not evaluable	ROB	-
Neonatal death (< 28 days of life)	0.93 [0.22, 3.89]	0%	4 studies	8	157	not evaluable	ROB	-
Neonatal disorders (as a whole)	1.13 [0.47, 2.74]	33%	3 studies	54	253	not evaluable	ROB	-
Fetal distress	0.63 [0.33, 1.19]	0%	3 studies	57	110	not evaluable	ROB	-
Hearing loss / Auditory deficit	1.12 [0.11, 11.06]	0%	3 studies		174	not evaluable	ROB	-
Low Apgar score (< 7) (at 5 min)	0.48 [0.17, 1.32]	0%	3 studies	20	146	not evaluable	ROB	-
Neonatal medical care	0.60 [0.35, 1.04]	0%	3 studies	80	137	not evaluable	ROB	-
Neonatal infections	0.92 [0.46, 1.83]	0%	2 studies	50	196	not evaluable	ROB	-
4 non statistically significant endpoints reported in only one study
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
4 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks)	0.73 [0.41, 1.30]	0%	13 studies	65	1,144	low	ROB	-
Early intrauterine death (< 22 weeks)	1.50 [1.10, 2.04]	0%	13 studies	225	903	probable	ROB	2.36 [1.43; .]
Intrauterine deaths (as a whole or unspecified)	1.13 [0.69, 1.85]	26%	6 studies	240	362	not evaluable	ROB	-
Elective/induced termination of pregnancy	2.42 [0.93, 6.29]	0%	3 studies	17	435	not evaluable	ROB	-
Therapeutic terminations of pregnancy	0.53 [0.02, 14.73]	56%	2 studies	3	412	not evaluable	ROB	-
1 non statistically significant endpoints reported in only one study
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neuro-developmental disorders (as a whole)	0.47 [0.18, 1.24]	0%	2 studies	28	175	not evaluable	ROB	-
4 non statistically significant endpoints reported in only one study