Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13648
R52926		 Chambers (Controls unexposed, disease free), 2022 Elective termination of pregnancy (for social or medical reason) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) Matched 1.00 [0.06;16.07] C
excluded (control group) 		1/279   1/279 2 279
ref
S13649
R52942		 Chambers (Controls unexposed, sick), 2022 Elective termination of pregnancy (for social or medical reason) at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) Matched 3.01 [0.12;74.23] C 1/279   0/279 1 279
ref
S13687
R53196		 Leroux, 2015 Elective termination throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.62 [0.02;15.60] C 0/41   1/77 1 41
ref
S13679
R53149		 Diav-Citrin, 2013 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 2.73 [0.95;7.83] C 6/115   9/455 15 115
ref
Total 3 studies 2.42 [0.93;6.29] 17 435
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls unexposed, sick), 2022Chambers, 2022 1 3.01[0.12; 74.23]12799%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Leroux, 2015Leroux, 2015 0.62[0.02; 15.60]1419%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Diav-Citrin, 2013Diav-Citrin, 2013 2.73[0.95; 7.83]1511582%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 2.42[0.93; 6.29]174350.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.42[0.93; 6.29]174350%NAChambers (Controls unexposed, sick), 2022 Leroux, 2015 Diav-Citrin, 2013 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.73[0.95; 7.83]15115 -NADiav-Citrin, 2013 1 unexposed, sickunexposed, sick 1.37[0.14; 13.34]23200%NAChambers (Controls unexposed, sick), 2022 Leroux, 2015 2 Tags Adjustment   - No  - No 2.42[0.93; 6.29]174350%NAChambers (Controls unexposed, sick), 2022 Leroux, 2015 Diav-Citrin, 2013 3 Indication HCQ   - Rheumatic diseases as a whole (Syst ...  - Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 2.75[1.01; 7.50]163940%NAChambers (Controls unexposed, sick), 2022 Diav-Citrin, 2013 2   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.62[0.02; 15.60]141 -NALeroux, 2015 1 MatchedMatched 3.01[0.12; 74.23]1279 -NAChambers (Controls unexposed, sick), 2022 1 All studiesAll studies 2.42[0.93; 6.29]174350%NAChambers (Controls unexposed, sick), 2022 Leroux, 2015 Diav-Citrin, 2013 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13648

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.40[0.90; 6.44]173940%NAChambers (Controls unexposed, disease free), 2022 Diav-Citrin, 2013 2 unexposed, sick controlsunexposed, sick controls 1.37[0.14; 13.34]23200%NAChambers (Controls unexposed, sick), 2022 Leroux, 2015 20.510.01.0