Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Oligohydramnios

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13715
R53423		 Seo, 2019 Oligohydramnios throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.88 [0.17;4.52] C 3/80   3/71 6 80
ref
S13687
R53199		 Leroux, 2015 Oligohydramnios throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.23 [0.03;1.94] C 1/38   8/77 9 38
ref
Total 2 studies 0.54 [0.15;1.96] 15 118
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo, 2019Seo, 2019 0.88[0.17; 4.52]68063%ROB confusion: seriousROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Leroux, 2015Leroux, 2015 0.23[0.03; 1.94]93837%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.54[0.15; 1.96]151180.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.54[0.15; 1.96]151180%NASeo, 2019 Leroux, 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.54[0.15; 1.96]151180%NASeo, 2019 Leroux, 2015 2 Tags Adjustment   - No  - No 0.54[0.15; 1.96]151180%NASeo, 2019 Leroux, 2015 2 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.54[0.15; 1.96]151180%NASeo, 2019 Leroux, 2015 2 All studiesAll studies 0.54[0.15; 1.96]151180%NASeo, 2019 Leroux, 2015 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.54[0.15; 1.96]151180%NASeo, 2019 Leroux, 2015 20.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period Duan (SLE indication)Duan (SLE indication) 0.90[0.38; 2.14]40%-unexposed, sickthroughout pregnancystudies3 metaPregmetaPreg 0.54[0.15; 1.96]0%118--Seo, 2019 Leroux, 2015 20.510.01.0