Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13715
R53425		 Seo, 2019 Early preterm (< 34 weeks’ gestation) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.37 [0.13;1.04] C 6/73   13/67 19 73
ref
S13699
R53334		 Kroese, 2017 Preterm live birth (< 34 weeks) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.29 [0.02;5.51] C 0/20   5/68 5 20
ref
S13687
R53201		 Leroux, 2015 Preterm birth (< 32 weeks) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.40 [0.02;8.49] C 0/38   2/77 2 38
ref
Total 3 studies 0.37 [0.14;0.92] 26 131
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo, 2019Seo, 2019 0.37[0.13; 1.04]197381%ROB confusion: seriousROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Kroese, 2017Kroese, 2017 0.29[0.02; 5.51]52010%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Leroux, 2015Leroux, 2015 0.40[0.02; 8.49]2389%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.37[0.14; 0.92]261310.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.37[0.14; 0.92]261310%NASeo, 2019 Kroese, 2017 Leroux, 2015 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.37[0.14; 0.92]261310%NASeo, 2019 Kroese, 2017 Leroux, 2015 3 Tags Adjustment   - No  - No 0.37[0.14; 0.92]261310%NASeo, 2019 Kroese, 2017 Leroux, 2015 3 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.37[0.14; 0.92]261310%NASeo, 2019 Kroese, 2017 Leroux, 2015 3 All studiesAll studies 0.37[0.14; 0.92]261310%NASeo, 2019 Kroese, 2017 Leroux, 2015 30.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.37[0.14; 0.92]261310%NASeo, 2019 Kroese, 2017 Leroux, 2015 30.510.01.0