Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13707
R53372		 Abd Rahman, 2020 Neonatal intensive care unit (NICU) admission during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.53 [0.13;2.18] 4/37   5/28 9 37
ref
S13773
R53893		 Baalbaki, 2020 Neonatal intensive care unit admission >72 h during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.52 [0.20;1.32] C 16/47   15/30 31 47
ref
S13654
R53032		 Do, 2020 Neonatal intensive care unit (NICU) admissions during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.69 [0.32;1.50] C 14/53   26/76 40 53
ref
Total 3 studies 0.60 [0.35;1.04] 80 137
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Abd Rahman, 2020Abd Rahman, 2020 0.53[0.13; 2.18]93715%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: unclearROB reporting: moderate Baalbaki, 2020Baalbaki, 2020 0.52[0.20; 1.32]314734%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Do, 2020Do, 2020 0.69[0.32; 1.50]405350%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.60[0.35; 1.04]801370.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.60[0.35; 1.04]801370%NAAbd Rahman, 2020 Baalbaki, 2020 Do, 2020 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.60[0.35; 1.04]801370%NAAbd Rahman, 2020 Baalbaki, 2020 Do, 2020 3 Tags Adjustment   - No  - No 0.60[0.35; 1.04]801370%NAAbd Rahman, 2020 Baalbaki, 2020 Do, 2020 3 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.60[0.35; 1.04]801370%NAAbd Rahman, 2020 Baalbaki, 2020 Do, 2020 3 All studiesAll studies 0.60[0.35; 1.04]801370%NAAbd Rahman, 2020 Baalbaki, 2020 Do, 2020 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.60[0.35; 1.04]801370%NAAbd Rahman, 2020 Baalbaki, 2020 Do, 2020 30.510.01.0