Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Neonatal disorders (as a whole)

id	Study   Auto Baalbaki, 2020Mollerach, 2019Cooper (controls exposed to TNF-I), 2014Cooper (controls unexposed, sick), 2014	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13773 R53891	Baalbaki, 2020	Neonatal composite (fetal death, NICU, neonatal death, intraventricular hemorrhage, sepsis, necrotizing enterocolitis, ...)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE)	0.62 [0.25;1.57] C	18/47   15/30	33	47		ref
S13713 R53412	Mollerach, 2019	Neonatal complications (NOS)	throughout pregnancy	retrospective cohort	unexposed, sick	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	3.87 [0.07;205.70] C	0/12   0/45	0	12		ref
S13651 R52961	Cooper (controls exposed to TNF-I), 2014	Neonatal complications	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.01 [0.32;3.20] C excluded (control group)	14/194   4/56	18	194		ref
S13652 R52991	Cooper (controls unexposed, sick), 2014	Neonatal complications	1st trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.82 [0.72;4.63] C	14/194   7/171	21	194		ref
					Total	3 studies	1.13 [0.47;2.74]		54	253
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 13651