Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13683
R53180		 Huybrechts (Controls unexposed, sick), 2021 Genital malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 1.16 [0.28;4.76] 12/2,045   118/21,679 130 2,045
ref
S13651
R52978		 Cooper (controls exposed to TNF-I), 2014 Genital defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 1.76 [0.21;14.89] C
excluded (control group) 		6/194   1/56 7 194
ref
S13652
R53008		 Cooper (controls unexposed, sick), 2014 Genital defects 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 11.82 [0.66;211.42] C 6/194   0/171 6 194
ref
Total 2 studies 2.60 [0.30;22.70] 136 2,239
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2021Huybrechts, 2021 1 1.16[0.28; 4.76]1302,04565%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Cooper (controls unexposed, sick), 2014Cooper, 2014 2 11.82[0.66; 211.42]619435%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 50% 2.60[0.30; 22.70]1362,2390.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.60[0.30; 22.70]1362,23950%NAHuybrechts (Controls unexposed, sick), 2021 Cooper (controls unexposed, sick), 2014 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.60[0.30; 22.70]1362,23950%NAHuybrechts (Controls unexposed, sick), 2021 Cooper (controls unexposed, sick), 2014 2 Tags Adjustment   - No  - No 11.82[0.66; 211.42]6194 -NACooper (controls unexposed, sick), 2014 1   - Yes  - Yes 1.16[0.28; 4.78]1302,045 -NAHuybrechts (Controls unexposed, sick), 2021 1 Indication HCQ   - Rheumatic diseases as a whole (Syst ...  - Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 2.60[0.30; 22.70]1362,23950%NAHuybrechts (Controls unexposed, sick), 2021 Cooper (controls unexposed, sick), 2014 2 All studiesAll studies 2.60[0.30; 22.70]1362,23950%NAHuybrechts (Controls unexposed, sick), 2021 Cooper (controls unexposed, sick), 2014 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13651

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.60[0.30; 22.70]1362,23950%NAHuybrechts (Controls unexposed, sick), 2021 Cooper (controls unexposed, sick), 2014 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.76[0.21; 14.89]7194 -NACooper (controls exposed to TNF-I), 2014 10.510.01.0