metaPreg - Bupropion (All indications except smoking cessation) during pregnancy

Bupropion (All indications except smoking cessation) updated on 10-20-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.05 [0.60, 1.82]	49%	5 studies	30,798	1,626	not evaluable	ROB	-
Major congenital malformations	1.05 [0.60, 1.82]	49%	5 studies	30,798	1,626	not evaluable	ROB	-
Congenital heart defects	1.03 [0.83, 1.28]	0%	3 studies	1,618	7,911	not evaluable	ROB	-
Ventricular septal defect	1.17 [0.69, 1.97]	59%	4 studies	3,518	7,945	not evaluable	ROB	-
Atrial septal defect	1.23 [0.66, 2.27]	0%	2 studies	1,142	21	not evaluable	ROB	-
Coarctation of aorta	1.00 [0.41, 2.43]	0%	2 studies	471	19	not evaluable	ROB	-
Hypoplastic left heart (HLH/HLHS)	2.07 [0.89, 4.79]	0%	2 studies	281	20	not evaluable	ROB	-
Limb defects	1.13 [0.50, 2.56]	0%	2 studies	10	1,213	not evaluable	ROB	-
Diaphragmatic hernia	2.77 [1.34, 5.72]	-	1 study			not evaluable	ROB	4.98 [2.02; .]
17 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	2.90 [0.15, 56.70]	61%	2 studies	307	407	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preeclampsia	1.07 [0.92, 1.25]	0%	2 studies	3,454	2,695	not evaluable	ROB	-
Postpartum hemorrhage	1.33 [0.99, 1.78]	0%	2 studies	5,069	1,217	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
7 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	2.63 [1.09, 6.36]	49%	4 studies	50	138	not evaluable	ROB	4.70 [1.40; .]
Therapeutic terminations of pregnancy	10.48 [1.32, 83.03]	-	1 study	11	136	not evaluable	ROB	20.44 [1.97; .]
2 non statistically significant endpoints reported in only one study
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
ADHD (Attention deficit hyperactivity disorder): Diagnosis	1.62 [0.65, 4.01]	59%	3 studies	1,081	19,462	not evaluable	ROB	-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk	1.62 [0.65, 4.01]	59%	3 studies	1,081	19,462	not evaluable	ROB	-
Psychomotor developmental disorders/delay	1.91 [1.16, 3.14]	-	1 study	131	19,341	not evaluable	ROB	3.23 [1.59; .]
7 non statistically significant endpoints reported in only one study