Bupropion (All indications except smoking cessation) updated on 07-01-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12927
R49053		 Anderson, 2020 Ventricular septal defect (VSD) – perimembranous type 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.97 [0.41;2.27] -/-   0/- - -
ref
S11716
R43066		 Huybrechts (Controls unexposed, NOS), 2014 Ventricular Septal Defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 1.22 [0.89;1.67]
excluded (control group) 		39/8,856   3,212/885,115 3,251 8,856
ref
S11717
R43070		 Huybrechts (Controls unexposed, sick), 2014 Ventricular Septal Defect 1st trimester cohort unexposed, sick Adjustment: Yes Indications Bupropion: Depression, mood or anxiety disorders Monotherapy: no or not specified Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified 0.86 [0.57;1.31] 26/6,696   751/180,564 777 6,696
ref
S12943
R49125		 Louik, 2014 Ventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.50 [1.30;5.00] 17/36   2,687/11,279 2,704 36
ref
S12933
R49087		 Cole, 2007 Ventricular septal defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 0.91 [0.40;2.08] C 7/1,213   30/4,743 37 1,213
ref
Total 4 studies 1.17 [0.69;1.97] 3,518 7,945
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.97[0.41; 2.27]--20%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Huybrechts (Controls unexposed, sick), 2014Huybrechts, 2014 1 0.86[0.57; 1.31]7776,69634%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Louik, 2014Louik, 2014 2.50[1.30; 5.00]2,7043625%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Cole, 2007Cole, 2007 0.91[0.40; 2.08]371,21321%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (4 studies) I2 = 59% 1.17[0.69; 1.97]3,5187,9450.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.60; 1.26]8147,9090%NAHuybrechts (Controls unexposed, sick), 2014 Cole, 2007 2 case control studiescase control studies 1.62[0.64; 4.08]2,7043666%NAAnderson, 2020 Louik, 2014 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.62[0.64; 4.08]2,7043666%NAAnderson, 2020 Louik, 2014 2 unexposed, sickunexposed, sick 0.86[0.57; 1.30]7776,696 -NAHuybrechts (Controls unexposed, sick), 2014 1 exposed to other treatment, sickexposed to other treatment, sick 0.91[0.40; 2.08]371,213 -NACole, 2007 1 Tags Adjustment   - No  - No 0.91[0.40; 2.08]371,213 -NACole, 2007 1   - Yes  - Yes 1.26[0.63; 2.51]3,4816,73272%NAAnderson, 2020 Huybrechts (Controls unexposed, sick), 2014 Louik, 2014 3 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 1.36[0.69; 2.69]2,7411,24956%NAAnderson, 2020 Louik, 2014 Cole, 2007 3   - Depression, mood or anxiety disorders  - Depression, mood or anxiety disorders 0.86[0.57; 1.30]7776,696 -NAHuybrechts (Controls unexposed, sick), 2014 1 Monotherapy   - no or not specified  - no or not specified 0.87[0.60; 1.26]8147,9090%NAHuybrechts (Controls unexposed, sick), 2014 Cole, 2007 2   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.62[0.64; 4.08]2,7043666%NAAnderson, 2020 Louik, 2014 2 Unexposed sick   - old history of illness/treatment (> ...  - old history of illness/treatment (> 12 months before pregnancy) or not specified 0.86[0.57; 1.30]7776,696 -NAHuybrechts (Controls unexposed, sick), 2014 1 All studiesAll studies 1.17[0.69; 1.97]3,5187,94559%NAAnderson, 2020 Huybrechts (Controls unexposed, sick), 2014 Louik, 2014 Cole, 2007 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.11.20.5240.000Anderson, 2020Huybrechts (Controls unexposed, sick), 2014Louik, 2014Cole, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 11716

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[0.87; 2.33]5,9558,89252%NAAnderson, 2020 Huybrechts (Controls unexposed, NOS), 2014 Louik, 2014 3 unexposed, sick controlsunexposed, sick controls 0.86[0.57; 1.30]7776,696 -NAHuybrechts (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.91[0.40; 2.08]371,213 -NACole, 2007 10.510.01.0